Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8216966 | 0.90 | MTOR (0.40) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL11926847 | 0.86 | MTOR (0.42) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL8214364 | 0.84 | MTOR (0.40) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL11925490 | 0.83 | MTOR (0.42) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL11925430 | 0.83 | MTOR (0.41) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL8212644 | 0.82 | PIK3CA (0.42) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL11926043 | 0.82 | MAPT (0.47) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL11925377 | 0.81 | MTOR (0.42) | MTORPIK3CAPIK3CGALDH1A1MAPT | |
| SCHEMBL11924689 | 0.81 | USP2 (0.46) | MTORPIK3CAPIK3CGALDH1A1KMT2A | |
| SCHEMBL11926799 | 0.80 | PIK3CA (0.43) | MTORPIK3CAPIK3CGALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |