Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.44 |
| ▸ | MTOR | P42345 | 10/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3592350 | 0.89 | PIK3CA (0.58) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL11898328 | 0.89 | PIK3CA (0.58) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL8212984 | 0.87 | PIK3CA (0.48) | PIK3CAMTORPIK3CGNPSR1PIK3CD | |
| SCHEMBL3929968 | 0.82 | ATR (0.55) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3606393 | 0.79 | PIK3CA (0.59) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3595305 | 0.78 | MTOR (0.70) | PIK3CAMTORPIK3CDCYP2C9 | |
| SCHEMBL3599055 | 0.77 | PIK3CA (0.61) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3602107 | 0.77 | PIK3CA (0.59) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL13257087 | 0.77 | PIK3CA (0.63) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL3588303 | 0.77 | PIK3CA (0.63) | PIK3CAMTORPIK3CGPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |