Beclomethasone

SCHEMBL8207142

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Beclomethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	8/20	0.84

▸	HIF1A	Q16665	9/20	0.84

▸	CYP3A4	P08684	7/20	0.84

▸	NFKB1	P19838	4/20	0.84

▸	HSD17B10	Q99714	4/20	0.84

▸	LMNA	P02545	4/20	0.84

▸	PGR	P06401	3/20	0.84

▸	TSHR	P16473	2/20	0.84

▸	AR	P10275	2/20	0.84

▸	PMP22	Q01453	2/20	0.84

▸	BLM	P54132	2/20	0.84

▸	ABCB11	O95342	2/20	0.84

▸	SMN1; SMN2	Q16637	2/20	0.84

▸	MEN1	O00255	1/20	0.84

▸	CYP2D6	P10635	1/20	0.84

▸	KMT2A	Q03164	1/20	0.84

▸	APEX1	P27695	1/20	0.84

▸	NPSR1	Q6W5P4	1/20	0.84

▸	MAPT	P10636	1/20	0.84

▸	GAA	P10253	1/20	0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Beclomethasone SCHEMBL991782	0.98	HIF1A (0.89)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Betamethasone SCHEMBL516602	0.94	HIF1A (0.95)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Dexamethasone SCHEMBL2637829	0.94	HIF1A (0.95)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Dexamethasone SCHEMBL1376472	0.94	HIF1A (0.95)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Clobetasol SCHEMBL8171593	0.92	HIF1A (0.87)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Betamethasone SCHEMBL24556970	0.92	HIF1A (1.00)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Betamethasone SCHEMBL21261932	0.92	HIF1A (1.00)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Betamethasone SCHEMBL13046610	0.92	HIF1A (1.00)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Betamethasone SCHEMBL21790369	0.92	HIF1A (1.00)	HIF1ANR3C1CYP3A4NFKB1HSD17B10
Betamethasone SCHEMBL20816248	0.92	HIF1A (1.00)	HIF1ANR3C1CYP3A4NFKB1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0977725-A1	NEW FATTY ACID DERIVATIVES	NORSK HYDRO ASA (NO)	2000-02-09	—	—	EP	disclosed
WO-1998032718-A1	NEW FATTY ACID DERIVATIVES	NORSK HYDRO ASA (NO)	1998-07-30	—	—	WO	disclosed