Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL576462 | 1.00 | KMT2A (0.63) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL523900 | 1.00 | KMT2A (0.63) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL27902911 | 1.00 | KMT2A (0.63) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL5626616 | 1.00 | KMT2A (0.63) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL576463 | 1.00 | KMT2A (0.63) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL4529849 | 1.00 | KMT2A (0.63) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL523899 | 1.00 | KMT2A (0.63) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL9987097 | 0.90 | KMT2A (0.53) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL14405525 | 0.89 | KMT2A (0.60) | KMT2AMAPK1BRD4GRM5HSD11B1 | |
| SCHEMBL20306298 | 0.87 | KMT2A (0.48) | KMT2AMAPK1BRD4HSD11B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812753-A | Substituted pyridopyrazines as syk inhibitors | HUTCHISON MEDIPHARMA LTD | 2015-07-29 | — | — | CN | disclosed |
| CN-101862317-A | The pregabalin derivant that is used for the treatment of fibromyalgia and other disease | WARNER LAMBERT CO | 2010-10-20 | — | — | CN | disclosed |
| CN-1310872-C | Mono- and disubstituted 3-propyl gamma-aminobutyric acids | WARNER LAMBERT CO (US) | 2007-04-18 | — | — | CN | disclosed |
| CN-1726023-A | Pregabalin derivatives for the treatment of fibromyalgia and other diseases | WARNER LAMBERT CO (US) | 2006-01-25 | — | — | CN | disclosed |
| CN-1660779-A | Mono- and disubstituted 3-propyl gamma-aminobutyric acids | WARNER LAMBERT CO (US) | 2005-08-31 | — | — | CN | disclosed |
| CN-1625393-A | Alpha 2 delta ligands to treat tinnitus | WARNER LAMBERT CO (US) | 2005-06-08 | — | — | CN | disclosed |
| CN-1196671-C | Mono-and disubstituted 3-propyl-gamma-aminobutyric acids | WARNER LAMBERT CO (US) | 2005-04-13 | — | — | CN | disclosed |
| CN-1355784-A | Mono-and disubstituted 3-propyl-gamma-aminobutyric acids | WARNER LAMBERT CO (US) | 2002-06-26 | — | — | CN | disclosed |
| US-6121272-A | Bidentate metalloprotease inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-19 | — | — | US | disclosed |