Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.84 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.84 |
| ▸ | STK10 | O94804 | 2/20 | 0.84 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.84 |
| ▸ | RET | P07949 | 2/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.84 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.84 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.84 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | KDR | P35968 | 16/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.76 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.76 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.76 |
| ▸ | ABL1 | P00519 | 1/20 | 0.76 |
| ▸ | EGFR | P00533 | 1/20 | 0.76 |
| ▸ | LCK | P06239 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brivanib Alaninate SCHEMBL13108648 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| Brivanib Alaninate SCHEMBL15971686 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| Brivanib Alaninate SCHEMBL28365380 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| Brivanib Alaninate SCHEMBL18319845 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| Brivanib Alaninate SCHEMBL29355920 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| Brivanib Alaninate SCHEMBL2263525 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| Brivanib Alaninate SCHEMBL29665039 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| Brivanib Alaninate SCHEMBL483382 | 0.91 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1227534 | 0.88 | KDR (0.83) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14387702 | 0.88 | CYP3A4 (1.00) | CYP3A4FGFR1CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042646-A1 | ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2009-04-02 | — | — | WO | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |