Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.37 |
| ▸ | TACR2 | P21452 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213419 | 0.88 | GRM2 (0.44) | GRM2GRIN1GRIN2BTACR2TACR1 | |
| SCHEMBL3073111 | 0.88 | GRM2 (0.50) | GRM2HRH3GRIN1GRIN2BTACR2 | |
| SCHEMBL3074732 | 0.87 | GRM2 (0.49) | GRM2ALDH1A1GRIN1GRIN2BTACR2 | |
| SCHEMBL3077894 | 0.86 | GRM2 (0.50) | GRM2HRH3GRIN1GRIN2B | |
| SCHEMBL3067967 | 0.85 | GRM2 (0.47) | GRM2HRH3GRIN1GRIN2BTACR2 | |
| SCHEMBL3058078 | 0.84 | GRM2 (0.47) | GRM2ALDH1A1GRIN1GRIN2BTACR2 | |
| SCHEMBL3077014 | 0.84 | GRM2 (0.52) | GRM2ALDH1A1HRH3GRIN1GRIN2B | |
| SCHEMBL3062958 | 0.84 | GRM2 (0.54) | GRM2ALDH1A1 | |
| SCHEMBL3066714 | 0.84 | GRM2 (0.52) | GRM2HRH3GRIN1GRIN2BGRM5 | |
| SCHEMBL3069947 | 0.83 | GRM2 (0.46) | GRM2HRH3GRIN1GRIN2BTACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032191-A2 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (US) | 2008-03-20 | — | — | WO | disclosed |