Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.80 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.80 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.80 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.80 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.80 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.80 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.80 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.78 |
| ▸ | ABL1 | P00519 | 2/20 | 0.78 |
| ▸ | INSR | P06213 | 2/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.78 |
| ▸ | CDK2 | P24941 | 2/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205533 | 0.96 | HDAC3 (0.87) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8213527 | 0.95 | HDAC3 (0.88) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4740260 | 0.93 | HDAC3 (0.90) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8212905 | 0.92 | EGFR (0.68) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13538227 | 0.92 | HDAC3 (0.78) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22338317 | 0.91 | EGFR (0.83) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15766160 | 0.91 | EGFR (0.83) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4334092 | 0.91 | EGFR (0.77) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12727523 | 0.90 | EGFR (0.87) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8215894 | 0.90 | HDAC3 (0.95) | EGFRHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009035718-A1 | TARTRATE SALTS OR COMPLEXES OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033749-A2 | QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |