Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209296 | 0.87 | MAPT (0.51) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL8213824 | 0.85 | MAPT (0.55) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL11621538 | 0.76 | MAPT (0.81) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4782773 | 0.75 | MAPT (0.67) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL14066861 | 0.75 | MAPT (0.61) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL12517440 | 0.74 | MEN1 (0.74) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL751290 | 0.73 | MAPT (0.60) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9969486 | 0.73 | MAPT (0.62) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL8209389 | 0.73 | MAPT (0.67) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9827893 | 0.72 | MAPT (0.70) | MAPTRAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033744-A2 | DNA METHYL TRANSFERASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |