Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 7/20 | 0.39 |
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935077 | 0.81 | PPARG (0.44) | HRH3PPARGPPARAEPHX2KCNH2 | |
| SCHEMBL1934851 | 0.78 | NPC1 (0.44) | HRH3PPARGPPARAFFAR4CYP3A4 | |
| SCHEMBL1935430 | 0.77 | PPARA (0.55) | PPARGPPARAPPARD | |
| SCHEMBL1934438 | 0.77 | FFAR4 (0.45) | HRH3PPARGPPARAEPHX2FFAR4 | |
| SCHEMBL3513426 | 0.76 | NPC1 (0.46) | HRH3EPHX2FFAR4MRGPRX4NPC1 | |
| SCHEMBL2153233 | 0.75 | PPARA (0.45) | HRH3PPARGPPARAEPHX2CYP3A4 | |
| SCHEMBL3512485 | 0.74 | PPARD (0.45) | HRH3PPARGPPARAEPHX2NPC1 | |
| SCHEMBL1934559 | 0.72 | PPARD (0.43) | HRH3PPARGPPARAEPHX2FFAR4 | |
| SCHEMBL19743127 | 0.70 | PPARG (0.44) | HRH3PPARGPPARAEPHX2FFAR4 | |
| SCHEMBL3513128 | 0.69 | PPARA (0.55) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046716-B1 | SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES THEREOF | GENFIT (FR) | 2013-08-14 | — | — | EP | claimed |
| US-8188148-B2 | Substituted 1,3-diphenylpropane derivatives, preparations and uses thereof | GENFIT (FR) | 2012-05-29 | — | — | US | claimed |