SCHEMBL8211779

SCHEMBL8211779

CCCCOc1cc(C=CC(=O)c2ccccc2)ncc1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.54
MAPT P10636 4/20 0.54
RAB9A P51151 4/20 0.54
ALDH1A1 P00352 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
BCHE P06276 6/20 0.48
LMNA P02545 1/20 0.48
DPP4 P27487 1/20 0.47
PTPN1 P18031 1/20 0.47
KMT2A Q03164 2/20 0.45
CYP3A4 P08684 1/20 0.45
NFKB1 P19838 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
ACHE P22303 2/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8211777 1.00 NPC1 (0.54) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8216223 0.90 NPC1 (0.50) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8216220 0.90 NPC1 (0.50) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8216300 0.88 NPC1 (0.48) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8218357 0.88 AKT1 (0.50) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8216297 0.88 NPC1 (0.48) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8218353 0.88 AKT1 (0.50) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8219209 0.88 NPC1 (0.60) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8219212 0.88 NPC1 (0.60) NPC1MAPTRAB9AALDH1A1SMN1; SMN2
SCHEMBL8211286 0.86 AKT1 (0.48) NPC1MAPTRAB9AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046218-A 4,5-DIMETHOXY-2-(3-OXO-3-PHENYL-1-PROPENYL)PYRIDINE USED TO CURE THE DISEASES PRODUCED BY CYTOKINE SS PHARMACEUTICAL CO., LTD. (JP) 2000-04-04 US disclosed
EP-0838457-A1 NOVEL PYRIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS ACTIVE INGREDIENT SS Pharmaceutical Co., Ltd. (JP) 1998-04-29 EP disclosed