Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 19/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 19/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 19/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 19/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 19/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 19/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 19/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 19/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 19/20 | 0.68 |
| ▸ | KDR | P35968 | 15/20 | 0.68 |
| ▸ | EGFR | P00533 | 5/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | BUB1 | O43683 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203947 | 0.92 | HDAC3 (0.66) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8216205 | 0.91 | HDAC3 (0.65) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL642654 | 0.89 | HDAC3 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12426806 | 0.88 | EGFR (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13928161 | 0.88 | HDAC3 (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL643113 | 0.85 | EGFR (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13809973 | 0.82 | HDAC3 (0.85) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL643572 | 0.81 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL642988 | 0.81 | HDAC3 (0.86) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2101009 | 0.81 | EGFR (0.81) | KDREGFRERBB2GAKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009035718-A1 | TARTRATE SALTS OR COMPLEXES OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2008033749-A2 | QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |