Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1181251 | 0.89 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181088 | 0.89 | HDAC3 (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180977 | 0.89 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180534 | 0.86 | PIK3CA (0.83) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181569 | 0.86 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12166287 | 0.85 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181360 | 0.85 | PIK3CD (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181125 | 0.84 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181334 | 0.84 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181981 | 0.84 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |