Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.42 |
| ▸ | MTOR | P42345 | 8/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.38 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213767 | 0.89 | GRM4 (0.43) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8212636 | 0.88 | NAMPT (0.42) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8214615 | 0.87 | KMT2A (0.49) | PIK3CAMTORPIK3CGPIK3CDKMT2A | |
| SCHEMBL8217167 | 0.83 | PIK3CA (0.40) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8216392 | 0.83 | KMT2A (0.46) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8212662 | 0.83 | KMT2A (0.44) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8206506 | 0.82 | POLB (0.45) | PIK3CAMTORPIK3CGPIK3CDNAMPT | |
| SCHEMBL8218182 | 0.81 | PIK3CA (0.51) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8212679 | 0.81 | PIK3CA (0.47) | PIK3CAMTORPIK3CGPIK3CDPIP4K2A | |
| SCHEMBL8217177 | 0.81 | PIK3CA (0.39) | PIK3CAMTORPIK3CGPIK3CDCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |