Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 4/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.58 |
| ▸ | PPARA | Q07869 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.53 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.53 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.53 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207328 | 0.89 | PPARA (0.58) | KMT2APPARAGSK3BBACE1SMN1; SMN2 | |
| SCHEMBL2776601 | 0.85 | GSK3B (0.76) | KMT2AMEN1GSK3BBACE1MAOB | |
| SCHEMBL2776603 | 0.85 | GSK3B (0.76) | KMT2AMEN1GSK3BBACE1MAOB | |
| SCHEMBL142092 | 0.83 | ABCG2 (0.62) | PPARAGSK3BSMN1; SMN2 | |
| SCHEMBL8782823 | 0.83 | ABCG2 (0.62) | PPARAGSK3BSMN1; SMN2 | |
| SCHEMBL451121 | 0.82 | S1PR1 (0.61) | AKR1B10AKR1B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL451122 | 0.82 | S1PR1 (0.61) | AKR1B10AKR1B1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9339002 | 0.82 | CA12 (0.57) | KMT2ALMNAPPARAGSK3BSMN1; SMN2 | |
| SCHEMBL9339004 | 0.82 | CA12 (0.57) | KMT2ALMNAPPARAGSK3BSMN1; SMN2 | |
| SCHEMBL14634380 | 0.82 | CA12 (0.57) | KMT2ALMNAPPARAGSK3BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033743-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |