Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 19/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.72 |
| ▸ | MTOR | P42345 | 3/20 | 0.72 |
| ▸ | PARP1 | P09874 | 1/20 | 0.65 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1182493 | 0.89 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181587 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181481 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1182122 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180960 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181480 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1182149 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180958 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180092 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1182148 | 0.88 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2518074-A1 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2012-10-31 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |