Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.81 |
| ▸ | BACE2 | Q9Y5Z0 | 12/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | CTSD | P07339 | 11/20 | 0.62 |
| ▸ | REN | P00797 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4888987 | 0.89 | BACE1 (0.78) | BACE1BACE2APPCTSDREN | |
| SCHEMBL5660194 | 0.89 | BACE1 (1.00) | BACE1BACE2APPCTSDREN | |
| SCHEMBL4884566 | 0.89 | BACE1 (0.76) | BACE1BACE2APPCTSDREN | |
| SCHEMBL8224091 | 0.87 | BACE1 (0.74) | BACE1BACE2APPCTSDREN | |
| SCHEMBL4883718 | 0.87 | BACE1 (0.76) | BACE1BACE2APPCTSDREN | |
| SCHEMBL4887997 | 0.87 | BACE1 (0.76) | BACE1BACE2APPCTSDREN | |
| Hydrochloric Acid SCHEMBL4248444 | 0.86 | BACE1 (0.72) | BACE1BACE2APPCTSDREN | |
| SCHEMBL5661819 | 0.86 | BACE1 (0.79) | BACE1BACE2APPCTSDREN | |
| SCHEMBL4891069 | 0.85 | BACE1 (0.71) | BACE1BACE2APPCTSDREN | |
| SCHEMBL4887607 | 0.85 | BACE1 (0.71) | BACE1BACE2APPCTSDREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145569-A9 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |