Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.57 |
| ▸ | PDCD1 | Q15116 | 14/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 14/20 | 0.50 |
| ▸ | ATR | Q13535 | 14/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.50 |
| ▸ | ATRIP | Q8WXE1 | 12/20 | 0.50 |
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591025 | 0.93 | PIK3CA (0.67) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL738650 | 0.79 | PIK3CA (0.72) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL3592699 | 0.79 | PIK3CA (0.66) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL3588507 | 0.78 | ATR (0.69) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL3605640 | 0.77 | PIK3CA (0.64) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL8219009 | 0.77 | PIK3CD (0.57) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL3594578 | 0.77 | PIK3CA (0.61) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL3592959 | 0.76 | PIK3CA (0.56) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL3605539 | 0.76 | PIK3CA (0.56) | PIK3CAPIK3CDPDCD1CD274ATR | |
| SCHEMBL3605555 | 0.76 | PDCD1 (0.71) | PIK3CAPIK3CDPDCD1CD274ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |