Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.41 |
| ▸ | MTOR | P42345 | 5/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218351 | 0.99 | PIK3CA (0.42) | PIK3CAMTORPIK3CGPIK3CDKMT2A | |
| SCHEMBL8205327 | 0.90 | PIK3CD (0.39) | PIK3CAPIK3CDKMT2ACYP3A4CYP2D6 | |
| SCHEMBL8213051 | 0.90 | PIK3CA (0.53) | PIK3CAMTORPIK3CGPIK3CDNAMPT | |
| SCHEMBL8214015 | 0.90 | CYP3A4 (0.49) | KMT2ACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8213031 | 0.89 | PIK3CD (0.40) | PIK3CAMTORPIK3CDKMT2APTGS2 | |
| SCHEMBL8213028 | 0.89 | CYP3A4 (0.48) | KMT2ACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11925981 | 0.89 | PIK3CA (0.53) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8213854 | 0.87 | PIK3CA (0.46) | PIK3CAMTORPIK3CGPIK3CDNAMPT | |
| SCHEMBL8213054 | 0.86 | PIK3CA (0.48) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8214220 | 0.84 | PIK3CA (0.48) | PIK3CAMTORPIK3CGPIK3CDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |