Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201363 | 0.92 | GRM5 (0.63) | GRM5KCNH2KMT2A | |
| SCHEMBL2963963 | 0.92 | GRM5 (0.63) | GRM5KCNH2KMT2A | |
| SCHEMBL13201362 | 0.84 | GRM5 (0.66) | GRM5KCNH2 | |
| SCHEMBL2966417 | 0.84 | GRM5 (0.66) | GRM5KCNH2 | |
| SCHEMBL2959176 | 0.77 | GRM5 (1.00) | GRM5KCNH2KMT2A | |
| SCHEMBL13201365 | 0.73 | GRM5 (0.62) | GRM5KCNH2 | |
| SCHEMBL2956435 | 0.73 | GRM5 (0.62) | GRM5KCNH2 | |
| SCHEMBL2959556 | 0.72 | GRM5 (1.00) | GRM5KCNH2 | |
| SCHEMBL2967887 | 0.72 | GRM5 (1.00) | GRM5KCNH2 | |
| SCHEMBL13201361 | 0.72 | GRM5 (0.66) | GRM5KCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041075-A1 | MGLUR5 MODULATORS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |