⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16949306 | 1.00 | — | — | |
| SCHEMBL8737440 | 1.00 | — | — | |
| SCHEMBL8737545 | 1.00 | — | — | |
| SCHEMBL13777918 | 0.80 | — | — | |
| SCHEMBL12753028 | 0.78 | — | — | |
| SCHEMBL1479776 | 0.78 | — | — | |
| SCHEMBL1479772 | 0.78 | — | — | |
| SCHEMBL15276137 | 0.76 | — | — | |
| SCHEMBL15276139 | 0.76 | — | — | |
| SCHEMBL6123176 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846934-B2 | Furo[3,2-B] pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors | AMURA THERAPEUTICS LIMITED (GB) | 2010-12-07 | — | — | US | disclosed |
| US-20090192170-A1 | Furo[3,2-B] pyrrol -3-one derivatives and their use as cysteinyl porteinase inhibitors | AMURA THERAPEUTICS LIMITED (GB) | 2009-07-30 | — | — | US | disclosed |
| WO-2008007112-A1 | TETRAHYDROFURO [3, 2-B] PYRR0L-3-ONES AS CATHEPSIN K INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |