Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221379 | 1.00 | GRM5 (0.54) | GRM5ALDH1A1TDP1GAAMAPT | |
| SCHEMBL8223870 | 0.88 | GRM5 (0.64) | GRM5ALDH1A1TDP1GAAMAPT | |
| SCHEMBL8214680 | 0.88 | GRM5 (0.64) | GRM5ALDH1A1TDP1GAAMAPT | |
| SCHEMBL1868540 | 0.88 | GRM5 (0.64) | GRM5ALDH1A1TDP1GAAMAPT | |
| SCHEMBL1872359 | 0.78 | GRM5 (0.61) | GRM5ALDH1A1TDP1GAAMAPT | |
| SCHEMBL1868610 | 0.77 | GRM5 (0.63) | GRM5ALDH1A1TDP1GAAMAPT | |
| SCHEMBL1868570 | 0.76 | GRM5 (0.56) | GRM5ALDH1A1HPGD | |
| SCHEMBL1869788 | 0.73 | GRM5 (0.58) | GRM5ALDH1A1TDP1GAAMAPT | |
| SCHEMBL3815158 | 0.73 | GRM5 (0.43) | GRM5 | |
| SCHEMBL1873246 | 0.73 | GRM5 (0.55) | GRM5ALDH1A1TDP1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054421-B1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2010-11-17 | — | — | EP | disclosed |
| WO-2008015270-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | disclosed |