Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | MTOR | P42345 | 6/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11925480 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8213961 | 0.87 | CA12 (0.47) | MEN1ALDH1A1KMT2A | |
| SCHEMBL8213896 | 0.86 | PIK3CA (0.53) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8212679 | 0.84 | PIK3CA (0.47) | PIK3CAPIK3CDMTORKMT2A | |
| SCHEMBL11925801 | 0.84 | CA12 (0.34) | PIK3CAPIK3CDMTORMEN1ALDH1A1 | |
| SCHEMBL8214756 | 0.83 | PIK3CA (0.55) | PIK3CAPIK3CDMTOR | |
| SCHEMBL11925797 | 0.83 | PIK3CA (0.49) | PIK3CAPIK3CDMTORKIF11KDM4E | |
| SCHEMBL8214040 | 0.82 | PIK3CA (0.54) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8206190 | 0.81 | PIK3CD (0.43) | PIK3CAPIK3CDMTORKIF11KDM4E | |
| SCHEMBL11926865 | 0.79 | PIK3CA (0.42) | PIK3CAPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |