Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335590 | 0.91 | NPC1 (0.50) | NPC1RAB9AALDH1A1LMNAEPHX2 | |
| SCHEMBL334997 | 0.83 | KIT (0.46) | NPC1RAB9AALDH1A1LMNAEPHX2 | |
| SCHEMBL335893 | 0.82 | KIT (0.49) | NPC1RAB9AALDH1A1LMNAEPHX2 | |
| SCHEMBL335307 | 0.81 | SMN1; SMN2 (0.47) | NPC1RAB9AALDH1A1LMNAEPHX2 | |
| SCHEMBL336153 | 0.80 | EPHX2 (0.47) | NPC1RAB9AALDH1A1LMNAEPHX2 | |
| SCHEMBL336282 | 0.79 | KIT (0.46) | NPC1RAB9AALDH1A1LMNAKIT | |
| SCHEMBL335151 | 0.79 | NPC1 (0.48) | NPC1RAB9AALDH1A1LMNAEPHX2 | |
| SCHEMBL335436 | 0.77 | NPC1 (0.53) | NPC1RAB9AALDH1A1LMNAEPHX2 | |
| SCHEMBL335878 | 0.74 | ABL1 (0.43) | LMNASMN1; SMN2MAPT | |
| SCHEMBL15291369 | 0.73 | ABL1 (0.41) | LMNAKITMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031509-A1 | ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXa INHIBITORS | SANOFI-AVENTIS (FR) | 2008-03-20 | — | — | WO | disclosed |