Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219482 | 1.00 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3HTR6ESR1 | |
| SCHEMBL8209011 | 0.93 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HTR6ESR1 | |
| SCHEMBL8209003 | 0.93 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HTR6ESR1 | |
| SCHEMBL8219768 | 0.82 | HTR2A (0.56) | SLC6A2SLC6A4SLC6A3HTR6ESR1 | |
| SCHEMBL8219769 | 0.82 | HTR2A (0.56) | SLC6A2SLC6A4SLC6A3HTR6ESR1 | |
| SCHEMBL7806031 | 0.78 | SLC6A4 (0.80) | SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL8216705 | 0.77 | HTR2A (0.54) | SLC6A2SLC6A4SLC6A3HTR6ESR1 | |
| SCHEMBL8216709 | 0.77 | HTR2A (0.54) | SLC6A2SLC6A4SLC6A3HTR6ESR1 | |
| SCHEMBL8208561 | 0.71 | ESR1 (0.50) | HTR6ESR1ESR2HTR2ASIGMAR1 | |
| SCHEMBL8107601 | 0.71 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3HTR6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000004017-A1 | AZABICYCLE-SUBSTITUTED PHENYLINDOLE DERIVATIVES AS LIGANDS FOR 5-HT2A RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2000-01-27 | — | — | WO | claimed |
| WO-2000004017-A1 | AZABICYCLE-SUBSTITUTED PHENYLINDOLE DERIVATIVES AS LIGANDS FOR 5-HT2A RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2000-01-27 | — | — | WO | disclosed |