Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219599 | 0.83 | FLT3 (0.49) | MAPTKMT2ANPSR1KDM4EALDH1A1 | |
| Ethane SCHEMBL28145480 | 0.76 | HDAC8 (0.53) | MAPTKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL217717 | 0.75 | HDAC8 (0.56) | MAPTKMT2AESR1KDM4EALDH1A1 | |
| SCHEMBL29672402 | 0.75 | HDAC8 (0.56) | MAPTKMT2AESR1KDM4EALDH1A1 | |
| Methane SCHEMBL27495395 | 0.73 | HDAC8 (0.59) | MAPTKMT2AESR1KDM4EALDH1A1 | |
| SCHEMBL28258037 | 0.73 | HDAC8 (0.54) | MAPTKMT2AESR1KDM4EALDH1A1 | |
| SCHEMBL3270763 | 0.71 | BRAF (0.50) | MAPTKMT2AUSP2NPSR1KDM4E | |
| SCHEMBL4025528 | 0.70 | NAMPT (0.50) | KMT2AESR1ALDH1A1HPGDSMN1; SMN2 | |
| Phenol SCHEMBL28500216 | 0.70 | CYP1A2 (0.46) | MAPTKMT2AESR1KDM4EALDH1A1 | |
| SCHEMBL8214582 | 0.70 | KMT2A (0.40) | MAPTKMT2AUSP2NPSR1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021960-A2 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |