Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1637122 | 0.93 | PDE10A (0.76) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL1639261 | 0.86 | PDE10A (0.85) | PDE10APDE3APDE3B | |
| SCHEMBL1638956 | 0.84 | PDE10A (0.83) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL1638948 | 0.83 | PDE10A (0.83) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL1638492 | 0.82 | PDE10A (1.00) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL1636932 | 0.81 | PDE10A (1.00) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL1638127 | 0.81 | PDE10A (1.00) | PDE10APDE3AACHEBACE1 | |
| SCHEMBL8225024 | 0.81 | PDE10A (0.75) | PDE10APDE3APDE3BACHEBACE1 | |
| SCHEMBL1636946 | 0.79 | PDE10A (1.00) | PDE10APDE3APDE3BHTR1A | |
| SCHEMBL28776954 | 0.79 | PDE10A (0.79) | PDE10APDE3APDE3BACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006372-A1 | (3-ARYL-PIPERAZIN-1-YL), (2-ARYL-MORPHOLIN-4-YL) AND (2-ARYL- THIOMORPHOLIN-4-YL) DERIVATIVES OF 6,7-DIALKOXYQUINAZOLINE, 6,7- DIALKOXYPHTALAZINE AND 6,7-DIALKOXYISOQUINOLINE | H. LUNDBECK A/S (DK) | 2008-01-17 | — | — | WO | disclosed |