Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220071 | 0.92 | BACE1 (0.45) | BACE1BACE2APPCTSDPOLB | |
| SCHEMBL4883509 | 0.86 | BACE1 (0.45) | BACE1BACE2APPCTSDPOLB | |
| SCHEMBL8224090 | 0.84 | BACE1 (0.44) | BACE1BACE2APPCTSDHDAC8 | |
| SCHEMBL13016530 | 0.79 | BACE1 (0.39) | BACE1BACE2APPCTSDPOLB | |
| SCHEMBL4887798 | 0.78 | BACE1 (0.44) | BACE1BACE2APPCTSDPOLB | |
| SCHEMBL13766659 | 0.78 | BACE1 (0.37) | BACE1BACE2APPCTSDPOLB | |
| SCHEMBL4883711 | 0.78 | BACE1 (0.48) | BACE1BACE2APPCTSD | |
| SCHEMBL14277041 | 0.77 | BACE1 (0.49) | BACE1BACE2APPCTSDPOLB | |
| SCHEMBL8217676 | 0.77 | BACE1 (0.37) | BACE1CTSDHDAC8HDAC5HDAC4 | |
| SCHEMBL4882001 | 0.76 | BACE1 (0.43) | BACE1BACE2APPCTSDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145569-A1 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-12-21 | — | — | WO | disclosed |