Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 18/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3482549 | 0.90 | ELANE (0.78) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL395327 | 0.90 | ELANE (0.78) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL394597 | 0.87 | ELANE (0.77) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL14899950 | 0.87 | ELANE (0.67) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL393057 | 0.86 | ELANE (0.81) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL393056 | 0.86 | ELANE (0.81) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL395516 | 0.81 | ELANE (0.72) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL8056317 | 0.79 | ELANE (0.65) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL391892 | 0.78 | ELANE (0.67) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL4449580 | 0.77 | ELANE (0.85) | ELANECYP2C9ADRB1HTR1AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008003412-A1 | THE USE OF 1,4-DIARYL-DIHYDROPYRIMIDINE-2-ON DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTENSION | BAYER HEALTHCARE AG (DE) | 2008-01-10 | — | — | WO | disclosed |