Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | IL6ST | P40189 | 5/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 3/20 | 0.38 |
| ▸ | IDH1 | O75874 | 4/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | FOS | P01100 | 1/20 | 0.32 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363549 | 1.00 | PIK3CD (0.50) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL6450650 | 1.00 | PIK3CD (0.50) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL8500845 | 0.86 | IL6ST (0.56) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL8500848 | 0.86 | IL6ST (0.56) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL6159017 | 0.84 | PIK3CD (0.53) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL6159024 | 0.84 | PIK3CD (0.53) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL3838379 | 0.84 | IL6ST (0.64) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL15619064 | 0.84 | IL6ST (0.64) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL3629926 | 0.83 | IL6ST (0.52) | PIK3CDIL6STSTAT3NAAAIDH1 | |
| SCHEMBL16000130 | 0.83 | IL6ST (0.52) | PIK3CDIL6STSTAT3NAAAIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621270-B1 | Piperazine derivatives as collagenase inhibitors | SANKYO CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-5643908-A | ANGIOGENESIS INHIBITOR, ANTITUMOR | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0621270-A1 | COLLAGENASE INHIBITOR | SANKYO COMPANY LIMITED (JP) | 1994-10-26 | — | — | EP | disclosed |