Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 11/20 | 0.62 |
| ▸ | F10 | P00742 | 10/20 | 0.62 |
| ▸ | PLG | P00747 | 8/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.62 |
| ▸ | PROC | P04070 | 1/20 | 0.62 |
| ▸ | F11 | P03951 | 1/20 | 0.56 |
| ▸ | TMPRSS11D | O60235 | 12/20 | 0.49 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.49 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156717 | 0.90 | F2 (0.59) | F2F10PLGKLKB1PROC | |
| SCHEMBL8289971 | 0.90 | F2 (0.59) | F2F10PLGKLKB1PROC | |
| SCHEMBL8221418 | 0.89 | F10 (0.52) | F2F10PLGKLKB1PROC | |
| SCHEMBL8291002 | 0.85 | F10 (0.56) | F2F10PLGKLKB1PROC | |
| SCHEMBL8291001 | 0.85 | F10 (0.56) | F2F10PLGKLKB1PROC | |
| SCHEMBL8289816 | 0.85 | F2 (0.54) | F2F10PLGKLKB1PROC | |
| SCHEMBL8289962 | 0.85 | F2 (0.54) | F2F10PLGKLKB1PROC | |
| SCHEMBL15248054 | 0.85 | F2 (0.70) | F2F10PLGKLKB1PROC | |
| SCHEMBL12044754 | 0.84 | F2 (0.60) | F2F10PLGKLKB1PROC | |
| SCHEMBL14567278 | 0.83 | F2 (0.55) | F2F10PLGKLKB1PROC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008049595-A9 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | CURACYTE DISCOVERY GMBH (DE) | 2009-01-29 | — | — | WO | disclosed |
| WO-2008049595-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, AND THEIR PREPARATION AND USE | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2008-05-02 | — | — | WO | disclosed |