Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.59 |
| ▸ | MGAM | O43451 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | RORC | P51449 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8223797 | 0.92 | GRM1 (0.59) | AMY1AALDH1A1KDM4EPOLBPTK2B | |
| SCHEMBL8225245 | 0.91 | GRM1 (0.62) | ALDH1A1SMN1; SMN2HPGDGRM1MEN1 | |
| SCHEMBL8219874 | 0.86 | GRM1 (0.60) | AMY1AALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL15062260 | 0.84 | POLQ (0.53) | AMY1AALDH1A1KDM4EPOLBPTK2B | |
| SCHEMBL1006724 | 0.84 | SMN1; SMN2 (0.67) | POLBSMN1; SMN2HSD17B10LMNAMAPT | |
| SCHEMBL8223635 | 0.83 | GRM1 (0.60) | ALDH1A1SMN1; SMN2HPGDHSD17B10GRM1 | |
| SCHEMBL3452916 | 0.83 | GRM1 (0.69) | ALDH1A1POLBSMN1; SMN2HPGDGRM1 | |
| SCHEMBL8223745 | 0.82 | GRM1 (0.70) | ALDH1A1SMN1; SMN2HPGDGRM1MEN1 | |
| SCHEMBL3451925 | 0.81 | GRM1 (0.69) | ALDH1A1POLBSMN1; SMN2HPGDGRM1 | |
| SCHEMBL8223001 | 0.81 | GRM1 (0.60) | AMY1AALDH1A1KDM4EPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820707-B2 | Heterocyclic derivatives | N.V. ORGANON (NL) | 2010-10-26 | — | — | US | disclosed |
| US-7820707-B2 | Heterocyclic derivatives | N.V. ORGANON (NL) | 2010-10-26 | — | — | US | disclosed |
| US-20080255086-A1 | Heterocyclic Derivatives | N.V. ORGANON (NL) | 2008-10-16 | — | — | US | disclosed |
| US-20080255086-A1 | Heterocyclic Derivatives | N.V. ORGANON (NL) | 2008-10-16 | — | — | US | disclosed |
| WO-2008003452-A1 | PYRAZOLEALKANAMIDE SUBSTITUTED THIOPHENES AS AMPA POTENTIATORS | N.V. ORGANON (NL) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255086-A1 | Heterocyclic Derivatives | GRIN2C, GRIN3A, GRIN1 | AMY1A 3822/4885ALDH1A1 453/4885KDM4E 2605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.