Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | CDK2 | P24941 | 11/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PKLR | P30613 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652444 | 0.88 | CDK2 (0.74) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL2243473 | 0.87 | MEN1 (0.72) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL2243271 | 0.86 | MAPT (0.71) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL2243629 | 0.84 | CDK2 (0.71) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL4651601 | 0.83 | CDK2 (0.79) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL18531470 | 0.81 | MAPT (0.64) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL18531434 | 0.78 | CDK2 (0.68) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL18531441 | 0.77 | MEN1 (0.62) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL15387205 | 0.77 | CDK2 (0.84) | PKMMEN1KMT2AMAPTLMNA | |
| SCHEMBL26979427 | 0.76 | CDK2 (0.71) | PKMMEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041140-A2 | SUBSTITUTED ARYL-INDOLE COMPOUNDS AND THEIR KYNURENINE/KYNURAMINE-LIKE METABOLITES AS THERAPEUTIC AGENTS | NEURIM PHARMACEUTICALS (1991) LTD. (US) | 2008-04-10 | — | — | WO | disclosed |