Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.53 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.53 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250592 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8205160 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL250593 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29443853 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14679922 | 0.90 | LRRK2 (0.73) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL249620 | 0.85 | LRRK2 (0.59) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL249621 | 0.85 | LRRK2 (0.59) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2132052 | 0.85 | LRRK2 (0.78) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1021460 | 0.85 | LRRK2 (0.78) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1021458 | 0.85 | LRRK2 (0.78) | LRRK2TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | claimed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-7638548-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-12-29 | — | — | US | disclosed |
| US-7638548-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-12-29 | — | — | US | disclosed |
| US-20080114013-A1 | SPIROINDOLINONE DERIVATIVES | LIU JIN-JUN | 2008-05-15 | — | — | US | disclosed |
| US-20080114013-A1 | SPIROINDOLINONE DERIVATIVES | LIU JIN-JUN | 2008-05-15 | — | — | US | disclosed |
| WO-2008055812-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | ERBB2, ABL1, IGF1R | LRRK2 19/4885TUBB4A 311/4885TUBB 299/4885 |
| US-20080114013-A1 | SPIROINDOLINONE DERIVATIVES | RB1, XPOT, PDK2 | LRRK2 267/4885TUBB4A 292/4885TUBB 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.