Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 18/20 | 0.45 |
| ▸ | AKT1 | P31749 | 17/20 | 0.45 |
| ▸ | AKT2 | P31751 | 17/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14304466 | 1.00 | AKT3 (0.45) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8226862 | 0.98 | AKT3 (0.45) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL12323842 | 0.93 | AKT1 (0.47) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8223663 | 0.93 | AKT1 (0.44) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL14302963 | 0.93 | AKT3 (0.44) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8223666 | 0.92 | AKT1 (0.47) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8224201 | 0.91 | AKT1 (0.44) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8226097 | 0.84 | AKT3 (0.55) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL14304014 | 0.84 | AKT3 (0.54) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL8226943 | 0.84 | AKT3 (0.46) | AKT3AKT1AKT2PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |