Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 17/20 | 0.42 |
| ▸ | JAK3 | P52333 | 16/20 | 0.42 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224443 | 1.00 | ALOX5AP (0.43) | ALOX5APFEN1JAK2JAK3JAK1 | |
| SCHEMBL8219667 | 0.89 | JAK2 (0.53) | ALOX5APFEN1JAK2JAK3JAK1 | |
| SCHEMBL8219671 | 0.89 | JAK2 (0.53) | ALOX5APFEN1JAK2JAK3JAK1 | |
| SCHEMBL6525003 | 0.86 | JAK2 (0.55) | ALOX5APFEN1JAK2JAK3JAK1 | |
| SCHEMBL8222508 | 0.86 | JAK2 (0.55) | ALOX5APFEN1JAK2JAK3JAK1 | |
| SCHEMBL8216745 | 0.84 | JAK2 (0.56) | ALOX5APFEN1JAK2JAK3JAK1 | |
| SCHEMBL8216749 | 0.84 | JAK2 (0.56) | ALOX5APFEN1JAK2JAK3JAK1 | |
| SCHEMBL6520396 | 0.84 | JAK2 (0.58) | JAK2JAK3JAK1 | |
| SCHEMBL8223240 | 0.84 | JAK2 (0.57) | JAK2JAK3JAK1 | |
| SCHEMBL6520499 | 0.84 | JAK2 (0.57) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475667-A1 | INHIBITORS OF JAK | F. Hoffmann-La Roche AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029804-A1 | INHIBITORS OF JAK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-17 | — | — | WO | disclosed |