Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.58 |
| ▸ | MC4R | P32245 | 2/20 | 0.54 |
| ▸ | REN | P00797 | 7/20 | 0.44 |
| ▸ | CTSD | P07339 | 3/20 | 0.44 |
| ▸ | CTSE | P14091 | 2/20 | 0.44 |
| ▸ | PGC | P20142 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22279596 | 0.87 | GBA1 (0.55) | GBA1MC4RRENCTSDCTSE | |
| SCHEMBL23951472 | 0.86 | MC4R (0.51) | GBA1MC4RTSHRHSD17B10 | |
| SCHEMBL13177228 | 0.82 | GBA1 (0.50) | GBA1MC4RRENCTSDCTSE | |
| SCHEMBL16841696 | 0.78 | CA1 (0.55) | GBA1TSHRHSD17B10 | |
| SCHEMBL7857698 | 0.78 | CA1 (0.55) | GBA1TSHRHSD17B10 | |
| SCHEMBL19879529 | 0.78 | CA1 (0.55) | GBA1TSHRHSD17B10 | |
| SCHEMBL6267681 | 0.78 | CA1 (0.55) | GBA1TSHRHSD17B10 | |
| SCHEMBL19224560 | 0.78 | CA1 (0.55) | GBA1TSHRHSD17B10 | |
| SCHEMBL8979913 | 0.78 | CA1 (0.55) | GBA1TSHRHSD17B10 | |
| SCHEMBL25575155 | 0.78 | CA1 (0.55) | GBA1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007140980-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |