Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.55 |
| ▸ | CTSD | P07339 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.31 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CHRND | Q07001 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881837 | 0.91 | BACE1 (0.66) | BACE1CTSDRXFP1BACE2 | |
| SCHEMBL4888786 | 0.83 | BACE1 (0.47) | BACE1CTSDRXFP1BACE2RORC | |
| SCHEMBL4886726 | 0.83 | BACE1 (0.46) | BACE1CTSDRXFP1BACE2RORC | |
| SCHEMBL4883711 | 0.82 | BACE1 (0.48) | BACE1CTSDRXFP1BACE2RORC | |
| SCHEMBL4884539 | 0.81 | BACE1 (0.44) | BACE1CTSDRXFP1BACE2RORC | |
| SCHEMBL4890877 | 0.81 | BACE1 (0.44) | BACE1CTSDRXFP1BACE2RORC | |
| SCHEMBL4887710 | 0.79 | BACE1 (0.42) | BACE1CTSDRXFP1BACE2RORC | |
| SCHEMBL4017195 | 0.78 | BACE1 (0.41) | BACE1CTSDRXFP1BACE2RORC | |
| SCHEMBL13933077 | 0.78 | BACE1 (0.41) | BACE1CTSDBACE2 | |
| SCHEMBL4010184 | 0.78 | BACE1 (0.41) | BACE1CTSDRXFP1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145569-A1 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-12-21 | — | — | WO | disclosed |