Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.73 |
| ▸ | CTSD | P07339 | 7/20 | 0.55 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CTSE | P14091 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4887800 | 0.90 | BACE1 (0.71) | BACE1CTSDBACE2KCNH2CTSE | |
| SCHEMBL4887753 | 0.90 | BACE1 (0.71) | BACE1CTSDBACE2KCNH2CTSE | |
| SCHEMBL4881847 | 0.90 | BACE1 (0.71) | BACE1CTSDBACE2KCNH2CTSE | |
| SCHEMBL4890992 | 0.88 | BACE1 (0.68) | BACE1CTSDBACE2KCNH2CTSE | |
| SCHEMBL4892509 | 0.87 | BACE1 (0.67) | BACE1CTSDBACE2KCNH2CTSE | |
| SCHEMBL4883545 | 0.87 | BACE1 (0.67) | BACE1CTSDBACE2CTSE | |
| SCHEMBL4888095 | 0.85 | BACE1 (0.64) | BACE1CTSDBACE2KCNH2CTSE | |
| SCHEMBL4890667 | 0.85 | BACE1 (0.64) | BACE1CTSDBACE2KCNH2CTSE | |
| SCHEMBL8223587 | 0.84 | BACE1 (0.71) | BACE1CTSDBACE2 | |
| SCHEMBL4884916 | 0.84 | BACE1 (1.00) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145569-A1 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-12-21 | — | — | WO | disclosed |