Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL3 | P20749 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12002312 | 0.84 | ACKR3 (0.50) | BCL3NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL30577399 | 0.72 | SMN1; SMN2 (0.63) | NPC1TP53RAB9ASMN1; SMN2ACKR3 | |
| SCHEMBL17754101 | 0.72 | SMN1; SMN2 (0.63) | NPC1TP53RAB9ASMN1; SMN2ACKR3 | |
| SCHEMBL28312306 | 0.72 | NPC1 (0.55) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL16431436 | 0.72 | BCL3 (1.00) | BCL3ALDH1A1 | |
| SCHEMBL17753663 | 0.72 | BRD4 (0.52) | NPC1TP53RAB9ASMN1; SMN2ACKR3 | |
| SCHEMBL24538336 | 0.70 | ABL1 (0.66) | NPC1TP53RAB9ASMN1; SMN2ACKR3 | |
| SCHEMBL17270326 | 0.70 | ACKR3 (0.74) | ACKR3ALDH1A1 | |
| SCHEMBL21644691 | 0.70 | KDM1A (0.55) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL30779571 | 0.70 | KDM1A (0.55) | NPC1TP53RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008007113-A2 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |