Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12292609 | 0.89 | MC4R (0.42) | HRH3MC4RPARP1PARP2 | |
| SCHEMBL12220054 | 0.89 | HRH3 (0.47) | HRH3MC4RHTR1AHTR7ALDH1A1 | |
| SCHEMBL12220056 | 0.89 | HRH3 (0.47) | HRH3MC4RHTR1AHTR7ALDH1A1 | |
| SCHEMBL12193970 | 0.88 | HRH3 (0.46) | HRH3MC4RHTR1AHTR7ALDH1A1 | |
| SCHEMBL680770 | 0.88 | HRH3 (0.46) | HRH3MC4RHTR1AHTR7ALDH1A1 | |
| SCHEMBL8226052 | 0.86 | MC4R (0.48) | HRH3MC4RALDH1A1 | |
| SCHEMBL8217371 | 0.86 | MC4R (0.48) | HRH3MC4RALDH1A1 | |
| SCHEMBL681221 | 0.85 | HRH3 (0.44) | HRH3MC4RHTR1AHTR7ALDH1A1 | |
| SCHEMBL12194524 | 0.85 | HRH3 (0.44) | HRH3MC4RHTR1AHTR7ALDH1A1 | |
| SCHEMBL2738777 | 0.81 | TACR2 (0.47) | HTR1AHTR7ALDH1A1LMNATNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |