Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 4/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 8/20 | 0.49 |
| ▸ | CDK1 | P06493 | 7/20 | 0.49 |
| ▸ | CDK2 | P24941 | 7/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.49 |
| ▸ | CCND1 | P24385 | 4/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.45 |
| ▸ | CCND3 | P30281 | 2/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233530 | 0.86 | CDK4 (0.57) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL8227614 | 0.81 | MAPK9 (0.57) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL8235114 | 0.80 | MAPK9 (0.56) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL8233261 | 0.76 | CDK4 (0.57) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL8227898 | 0.75 | IKBKB (0.60) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL8228078 | 0.75 | MAPK8 (0.54) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL8235871 | 0.75 | CDK4 (0.58) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL8233932 | 0.72 | CDK1 (0.56) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL23838253 | 0.72 | PIK3C3 (0.59) | MAPK9MAPK8MAPK10CDK4CDK1 | |
| SCHEMBL18480113 | 0.72 | PIK3C3 (0.61) | MAPK9MAPK8MAPK10CDK4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |