Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221492 | 0.90 | SMO (0.64) | SMONPC1RAB9AKMT2ATP53 | |
| SCHEMBL8224616 | 0.87 | SMO (0.65) | SMONPC1RAB9AKMT2ATP53 | |
| SCHEMBL15492214 | 0.84 | KCNK3 (0.57) | SMONPC1RAB9AKMT2ATP53 | |
| SCHEMBL8219590 | 0.84 | SMO (0.79) | SMOKMT2AMEN1POLB | |
| SCHEMBL11911362 | 0.83 | SMO (0.60) | SMOKMT2AMEN1POLBRXFP1 | |
| SCHEMBL8211832 | 0.82 | SMO (0.62) | SMONPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8224661 | 0.81 | SMO (0.64) | SMOKMT2ASMN1; SMN2MEN1POLB | |
| SCHEMBL8224548 | 0.81 | SMO (0.78) | SMOKMT2AMEN1POLB | |
| SCHEMBL8211867 | 0.81 | SMO (0.77) | SMOKMT2AMEN1POLB | |
| SCHEMBL8234990 | 0.80 | SMO (0.61) | SMONPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456754-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | Universite De Strasbourg (FR) | 2012-05-30 | — | — | EP | claimed |
| WO-2011010013-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-01-27 | — | — | WO | claimed |