Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.56 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233538 | 0.80 | BACE1 (0.62) | BACE1CTSDBACE2 | |
| SCHEMBL8223183 | 0.79 | BACE1 (0.61) | BACE1CTSDBACE2 | |
| SCHEMBL4010085 | 0.76 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| Acetic Acid SCHEMBL4011607 | 0.75 | BACE1 (0.58) | BACE1CTSDBACE2 | |
| SCHEMBL4881409 | 0.72 | BACE1 (1.00) | BACE1CTSDBACE2 | |
| Acetic Acid SCHEMBL4305088 | 0.72 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL4013939 | 0.72 | BACE1 (0.74) | BACE1CTSDBACE2 | |
| SCHEMBL5096595 | 0.70 | BACE1 (0.76) | BACE1CTSDBACE2 | |
| SCHEMBL8224687 | 0.69 | BACE1 (0.68) | BACE1CTSDBACE2 | |
| SCHEMBL8230994 | 0.69 | BACE1 (1.00) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145571-A9 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |
| WO-2007145571-A1 | AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-12-21 | — | — | WO | disclosed |