Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14155991 | 0.92 | HDAC1 (0.63) | HDAC1HDAC3HDAC2HDAC8NAMPT | |
| SCHEMBL3642910 | 0.83 | HDAC1 (0.76) | HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL4580081 | 0.79 | HDAC1 (0.82) | HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL8292317 | 0.77 | HDAC1 (0.56) | HDAC1HDAC3HDAC2HDAC8NAMPT | |
| SCHEMBL13833519 | 0.77 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL30118374 | 0.77 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL3642412 | 0.76 | HDAC1 (0.73) | HDAC1HDAC3HDAC2HDAC8NAMPT | |
| SCHEMBL4579866 | 0.76 | HDAC1 (0.50) | HDAC1HDAC3HDAC2HDAC8LMNA | |
| SCHEMBL13833383 | 0.74 | HDAC1 (0.70) | HDAC1HDAC3HDAC2 | |
| SCHEMBL3645718 | 0.73 | HDAC1 (0.81) | HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007118137-A1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2007-10-18 | — | — | WO | disclosed |