Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561882 | 0.89 | CYP1A2 (0.51) | NOTUMELANECYP1A2NPSR1KDM4E | |
| SCHEMBL8234892 | 0.87 | NOTUM (0.52) | NOTUMELANECYP1A2MEN1KMT2A | |
| SCHEMBL984085 | 0.87 | NOTUM (0.64) | NOTUMELANECYP1A2KMT2AMAPT | |
| SCHEMBL2272178 | 0.86 | ELANE (0.56) | NOTUMELANECYP1A2KDM4EBRD9 | |
| SCHEMBL27716691 | 0.86 | NOTUM (0.53) | NOTUMELANECYP1A2MEN1KMT2A | |
| SCHEMBL4152986 | 0.82 | ELANE (0.50) | NOTUMELANECYP1A2MAPTBRD9 | |
| SCHEMBL4137643 | 0.82 | PDE4B (0.50) | NOTUMELANEMEN1KMT2ATP53 | |
| SCHEMBL596837 | 0.82 | CYP1A2 (0.52) | NOTUMELANECYP1A2MEN1KMT2A | |
| SCHEMBL8053624 | 0.80 | ELANE (0.49) | NOTUMELANECYP1A2NPSR1KDM4E | |
| SCHEMBL1604233 | 0.79 | KDM4E (0.49) | NOTUMELANEKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007107706-A2 | DIMERS OF HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF COPD | ARGENTA DISCOVERY LIMITED (GB) | 2007-09-27 | — | — | WO | disclosed |