Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.59 |
| ▸ | CDK1 | P06493 | 5/20 | 0.59 |
| ▸ | CDK4 | P11802 | 5/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.59 |
| ▸ | CCND1 | P24385 | 5/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 10/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CCND3 | P30281 | 1/20 | 0.55 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311762 | 0.88 | CDK1 (0.74) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8236156 | 0.87 | CDK2 (0.70) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8233754 | 0.87 | CDK1 (0.60) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8236618 | 0.79 | CDK2 (0.56) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8235683 | 0.78 | MAPK10 (0.48) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL5418915 | 0.77 | MAPK8 (0.72) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8236067 | 0.76 | CDK2 (0.51) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8234862 | 0.76 | CDK2 (0.50) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8236672 | 0.75 | CDK2 (0.55) | CDK2CDK1CDK4CCNB1CCNA2 | |
| SCHEMBL8228096 | 0.75 | MAPK10 (0.47) | CDK2CDK1CDK4CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |