Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12363616 | 0.91 | PDE4B (0.74) | PDE4BADORA1PDE5A | |
| SCHEMBL4940780 | 0.91 | PDE4B (0.74) | PDE4BADORA1PDE5A | |
| SCHEMBL4931414 | 0.91 | PDE4B (0.74) | PDE4BADORA1PDE5A | |
| SCHEMBL4935529 | 0.87 | PDE4B (0.62) | PDE4BADORA1PDE5A | |
| SCHEMBL4934425 | 0.87 | PDE4B (0.62) | PDE4BADORA1PDE5A | |
| SCHEMBL14034599 | 0.87 | PDE4B (0.62) | PDE4BADORA1PDE5A | |
| SCHEMBL3286186 | 0.86 | PDE4B (0.79) | PDE4BADORA1PDE5A | |
| SCHEMBL8230238 | 0.85 | PDE4B (0.60) | PDE4BADORA1PDE5A | |
| SCHEMBL8279380 | 0.85 | PDE4B (0.61) | PDE4B | |
| SCHEMBL8279419 | 0.85 | PDE4B (0.61) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009735-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |