Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 12/20 | 0.70 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916818 | 0.85 | GALR3 (0.68) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL916817 | 0.85 | GALR3 (0.68) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL916454 | 0.85 | GALR3 (0.68) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL917358 | 0.85 | GALR3 (0.72) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL916453 | 0.85 | GALR3 (0.68) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL917357 | 0.85 | GALR3 (0.72) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL916941 | 0.82 | GALR3 (0.64) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL916940 | 0.82 | GALR3 (0.64) | GALR3HTR4MAPTKMT2ATTR | |
| SCHEMBL13495845 | 0.82 | GALR3 (0.78) | GALR3HTR4MAPTKMT2AMEN1 | |
| SCHEMBL916990 | 0.82 | GALR3 (1.00) | GALR3HTR4DRD5ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241316-A1 | Indolone compounds useful to treat cognitive impairment | Helicon Therapeutics, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| EP-1957067-B1 | INDOLONE COMPOUNDS USEFUL TO TREAT COGNITIVE IMPAIRMENT | HELICON THERAPEUTICS INC (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2008002946-A2 | METHOD OF MODULATING NEURITE OUTGROWTH BY THE USE OF A GALANIN-3 RECEPTOR ANTAGONIST | HELICON THERAPEUTICS, INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| WO-2007070362-A1 | INDOLONE COMPOUNDS USEFUL TO TREAT COGNITIVE IMPAIRMENT | HELICON THERAPEUTICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| WO-2004093789-A2 | USE OF GALR3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |