SCHEMBL8230447

SCHEMBL8230447

Cc1ccc(-c2nc(C(=O)NC3CCCCC3)n(C)c2-c2ccc(I)cc2)c(Cl)c1

nearest known ligand 0.75

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 18/20 0.75
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
OPRL1 P41146 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL675796 0.86 CNR1 (1.00) CNR1OPRL1
SCHEMBL4079314 0.86 CNR1 (1.00) CNR1OPRL1
SCHEMBL4080151 0.85 CNR1 (1.00) CNR1OPRL1
SCHEMBL1315944 0.81 CNR1 (1.00) CNR1NPC1RAB9A
SCHEMBL4078172 0.81 CNR1 (1.00) CNR1
SCHEMBL4087802 0.80 CNR1 (0.82) CNR1
SCHEMBL674885 0.78 CNR1 (1.00) CNR1OPRL1
SCHEMBL4076305 0.78 CNR1 (1.00) CNR1
SCHEMBL13722373 0.77 CNR1 (0.85) CNR1OPRL1
SCHEMBL4083489 0.77 CNR1 (0.85) CNR1OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007125049-A1 USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-08 WO disclosed
WO-2007125048-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CBX CANNABINOID RECEPTOR MODULATORS AND POTASSIUM CHANNEL MODULATORS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-08 WO disclosed