Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381666 | 0.88 | JAK2 (0.75) | JAK2JAK3AKT3DGAT1CDC7 | |
| SCHEMBL4380086 | 0.86 | JAK2 (0.75) | JAK2JAK3AKT3DGAT1CDC7 | |
| SCHEMBL4374519 | 0.85 | JAK2 (0.75) | JAK2JAK3AKT3DGAT1CDC7 | |
| SCHEMBL4385023 | 0.85 | JAK2 (1.00) | JAK2JAK3POLBHDAC1 | |
| SCHEMBL4381813 | 0.83 | JAK2 (0.71) | JAK2JAK3AKT3DGAT1BRAF | |
| SCHEMBL4454789 | 0.83 | JAK2 (0.71) | JAK2JAK3AKT3DGAT1HDAC1 | |
| SCHEMBL4375319 | 0.82 | JAK2 (0.69) | JAK2ABL1EGFRSRCBCR | |
| SCHEMBL4380093 | 0.81 | JAK2 (0.68) | JAK2JAK3HDAC1 | |
| SCHEMBL4383184 | 0.81 | JAK2 (0.76) | JAK2JAK3POLBABL1SRC | |
| SCHEMBL4383774 | 0.80 | JAK2 (0.78) | JAK2JAK3DGAT1POLBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |